Stimuli-responsive nanomedicines have been utilized for targeted imaging and therapy of various intractable diseases (cancer, rheumatoid arthritis, diabetes, etc). For spatiotemporally controlled action of nanomedicines, they are designed to respond to specific microenvironments and be activated upon internal/external stimuli. Our research interests focus on the development of stimuli-responsive nanomedicine based on organic/inorganic materials in diverse approaches, such as enhanced chemotherapy, photo/sonodynamic therapy, imaging-guided therapy.